Products from BPS Bioscience require a minimum order value above 400€
Applications: Screen compound activity on the STAT3 signaling pathwayScreen inhibitors of STAT3-mediated IL-6 signaling
Background: The JAK-STAT signaling pathway is involved in both cancer and autoimmune disease and has been an attractive target for drug discovery. In the context of immune regulation, STAT3 is expressed in diverse cell types. While it was initially described as an acute phase response factor in the context of IL-6 signaling, STAT3 has since been identified as a downstream regulator of many cytokines. STAT3 can also be activated downstream of Type1 Interferons, such as IFN-alpha, where it may function as a negative regulator of Type1 interferon signaling. Studies of the JAK-STAT signaling pathways can prove useful in furthering our understanding of immunological diseases and cancer.
Description: The STAT3 Reporter Jurkat cell line is designed for monitoring the STAT3 signal transduction pathway. It contains a firefly luciferase gene driven by STAT3 response elements located upstream of the minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT3 binds to the DNA response elements, inducing transcription of the luciferase reporter gene.
Host Cell Line: Jurkat (clone E6-1), human T lymphoblast, suspension
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains ~2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Uniprot: P40763
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
English
Deutsch
