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Applications: Monitor TDO pathway activity. Screen for activators or inhibitors of TDO in a cellular context
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis inmammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a keyregulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains animmunosuppressive microenvironment by starving immune cells of L-Trp and releasingdegradation products of L-Trp that have immunosuppressive functions. Tryptophan 2,3dioxygenase (TDO), is upregulated in many tumors, providing cancer cells with an avenue forimmune evasion.
Description: Stable recombinant HEK293 cell line expressing human tryptophan 2,3 dioxygenase (TDO2, TDO, TPH2, TRPO), Genbank accession number NM_005651.
Format: Aqueous solution containing DMSO
Genbank: NM_005651.1
Host Cell Line: HEK293
Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit(Sigma-Aldrich) to confirm the absence of Mycoplasma species.
Storage Stability: Immediately upon receipt, store vials in liquid nitrogen
Supplied As: Each vial contains 1.75 X 10(6) cells in 1 ml of 10% DMSO
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-2
References: 1. Liu, X., et al., Blood. 2010; 115(17): 3520-3530.
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