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Applications: Screen and characterize TNFR2 antibodies.Study TNFR2 signaling in HEK293 cells.
Background: Tumor Necrosis Factor Receptor 2 (TNFR2, also known as TNFRSF1B or CD120b) is a transmembrane receptor of the TNF protein superfamily that binds the pleiotropic pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). TNFR2 can be found in several T-Cell subsets such as regulatory CD8+ T-Cells (Tregs) and CD4+ tumor-infiltrating T cells, myeloid lineage cells and some cancer types, and it is involved in autoimmune diseases, graft versus host disease and cancer. It has become an attractive target for cancer immunotherapy, where its different functions as oncogene and immune regulator are being explored. TNFR2 also exhibits neuroprotective properties and promotes tissue regeneration, making it a promising potential therapeutic target for the treatment of Alzheimer's disease.
Description: Recombinant HEK293 cell line constitutively expressing human TNFR2 gene (TNFRSF1B or CD120b, NM_001066.3) under the control of the CMV promoter.
Host Cell Line: HEK293, Human Embryonic Kidney, epithelial-like cells, adherent
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)
Uniprot: P20333
Warnings: Avoid freeze/thaw cycles
Biosafety Level: BSL-2
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