Kategorie: Cytokines
Formulation: solution
Storage: -20°C
Weight: 25100 D
Purity: >90%
Description: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated polypeptide chain containing 231 amino acids. APM-1 plays a role in various physiological processes such as energy homeostasis and obesity.
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