Cerebral Dopamine Neurotrophic Factor, mouse recombinant (rmCDNF)

Kategorie: Cytokines

Formulation: lyophilized

Storage: -20°C

Weight: 18500 D

Purity: >97%

Description: CDNF mouse recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 163 amino acids and having a molecular mass of 18.5 kDa. CDNF is a member of the ARMET family and acts as a trophic factor for dopamine neurons. CDNF inhibits the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When CDNF controlled after 6-OHDA-lesioning, it reestablishes the dopaminergic function and inhibits the degeneration of dopaminergic neurons in substantia nigra. CDNF is universally expressed in neuronal and non-neuronal tissues. The highest levels in the brain are found in the optic nerve and corpus callosum. CDNF mouse is able to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons when immobilized at 5 -3 0 µg/mL on a nitrocellulose-coated microplate.

• SKU: BOL97638.20
• Manufacturer: Biomol
• Manufacturer SKU: 97638.20
• Green Labware: No
• Package Unit: 20 µg
• Quantity Unit: STK
• Reactivity: Mouse (Murine)
• Human Gene ID: 227526
• Host: Escherichia Coli