FAS Ligand, His tag, human recombinant (rHuFASL-His)

Kategorie: Cytokines

Formulation: solution

Storage: -20°C

Weight: 19600 D

Purity: >90%

Description: FASLG human recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 173 amino acids (130-281) and having a molecular mass of 19.6 kDa. FASLG is fused to a 21 amino acid His-tag at N-terminus. The type II transmembrane protein FASLG is a member of the tumor necrosis factor (TNF) superfamily. A fas ligand/receptor interaction has a significant part in the regulation of the immune system and the advancement of cancer. FASLG is expressed on the activated T cell surface as a nondisulfidelinked homotrimer. FASLG binding to Fas/CD95/TNFRSF6 on a nearby cell prompts apoptosis in the Fas expressing cell. FASLG is released from the cell surface by metalloproteinases as a soluble molecule that stays trimeric and is able to bind with Fas, but its capability to activate apoptosis is radically reduced. In addition, FASLG binds to DcR3 - a soluble trap receptor with no signal transduction capabilities. Flawed Fas-mediated apoptosis causes oncogenesis in addition to drug resistance in existing tumors. Constitutive expression of FASLG in a variety of tumors enables their immune evasion. Both mouse and human FASLG are active on mouse and human cells.

• SKU: BOL97628.5
• Manufacturer: Biomol
• Manufacturer SKU: 97628.5
• Green Labware: No
• Package Unit: 5 µg
• Quantity Unit: STK
• Reactivity: Human
• Human Gene ID: 356
• Host: Escherichia Coli