Kategorie: Cytokines
Formulation: purified
Storage: -20°C
Purity: >95%
Description: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. (www.uniprot.org) Human recombinant Fractalkine produced in E.coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids (fragment 25-100) having a total molecular mass of 17.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. Fractalkine soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. Fractalkine membrane-bound form promotes adhesion of those leukocytes to endothelial cells. Fractalkine regulates leukocyte adhesion and migration processes at the endothelium and binds to CX3CR1. Natural human Fractalkine is produced as a long protein (373-amino acid) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the cell surface. Fractalkine gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.
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