Description: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. (www.uniprot.org) Produced in E.coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and an additional Ala at N-terminus, having PEG 20kD.