Product Description: The product contains the polyhedrin protein co-crystalized with Human BMP-7. BMP-7, also known as Bone Morphogenetic Protein 7, osteogenic protein-1 or OP-1, is a member of the TGF superfamily of proteins. Akin to the other functionally and structurally related bone morphogenic proteins (BMPs), BMP-7 is involved in cartilage and bone formation and signals through serine/threonine kinase receptors. Additionally, BMP-7 plays a role in a variety of other organs and organ systems such as during development of the kidney and prostate. Furthermore, BMP-7 has been identified as an anti-fibrotic molecule, antagonizing TGF-β1 and the emergence of fibroblasts derived from endothelial cells in fibrosis of kidney, lung, liver, heart and peritoneum. BMP-7 was also implicated in the promotion of neuroregeneration following brain ischemia. The BMP-7 protein is usually a disulfide-linked homodimer and highly conserved across animal species; for example, the amino acid sequence of human, mouse and rat BMP-7 are 98% identical. However, mature BMP-7 can also form disulfide-linked heterodimers with either BMP-2 or BMP-4. These hetrodimeric complexes have shown increased effects and range of activity compared to BMP-7 homodimers.
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