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Applications: Useful for protein binding assays, screening inhibitors, and selectivity profiling.
Background: The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template.
Description: Human chromodomain helicase DNA binding protein 2, or CHD2, (GenBank Accession No. NM_001271) a.a. 260-456(end), with N-terminal GST-tag, MW=49.3 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_001271
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: O14647
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Woodage, T., et al., Proc Natl Acad Sci
USA. 1997 Oct 14;94(21):11472-7.
2. Harada, A., et al., EMBO J. 2012 May
8;31(13):2994-3007.
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