Chloroquine diphosphate, CAS 50-63-5

Autophagy inhibitor

Product Type: Inhibitor

CAS No.: 50-63-5

MolecularFormula: C18H26ClN3·2H3PO4

Molecular Weight: 515,86

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in water (25mg/mL)

Appearance: Beige Solid

PubChem CID: 64927

Scientific Background: Chloroquine diphosphate was originally developed as a treatment against malaria. It has since been implicated in cancer research as it inhibits cell growth and induces cell death in a number of cancer cell lines. Chloroquine also inhibits autophagy by specifically blocking acidification of the lysosomes which fuse with autophagosomes. This consequently prevents the degradation of materials.

References: 1. Jiang P.D., et al. (2010) Biomed Pharmacother. 64(9): 609-14.2. Egger M.E., et al. (2013) J Surg Res. 184(1): 274-81.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-405-1G
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-405-1G
• Green Labware: No
• Package Unit: 1 g
• Quantity Unit: STK