Notes: Citrullinated Collagen Type II (R360+R365) (358-368)-biotin peptide is a biotinylated version of a di-citrullinated form of the fibril-forming heterotrimeric protein collagen type II, which undergoes citrullination by peptidyl arginine deiminase 2 (PAD2) and PAD4.{28017} It has been found in synovial fluid isolated from patients with rheumatoid arthritis.{28017,55746} Cayman's Citrullinated Collagen Type II (R360+R365) (358-368)-biotin Peptide is intended for the detection of autoantibodies against collagen type II citrullinated at R360 and R365.