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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. Activating mutations in cKIT are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, and acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.
Description: The cKIT Assay Kit is designed to measure cKIT activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The cKIT Assay Kit comes in a convenient 96-well format, with enough purified recombinant cKIT enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Picardo, M., Cardinali, G. J Invest Dermatol. 2011 Jun; 131(6): 1182-5. 2. Yarden, Y., et al. EMBO J. 1987; 6(11): 3341-51.
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