CL4F8-6, CAS 2766493-12-1

Formulation: A solution in ethanol

Formal Name: 7-(4-(dipropylamino)butyl)-7-hydroxytridecane-1,13-diyl bis(2-hexyloctanoate)

Purity: ≥98%

Formula Markup: C51H101NO5

Formula Weight: 808,4

Shelf life (days): 365

CAS Number: 2766493-12-1

Notes: CL4F8-6 is an ionizable cationic lipid (pKa = 6.14) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).{66447} Intravenous administration of LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing CL4F8-6 and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA (sgRNA) targeting Ttr (sgTtr), the gene encoding transthyretin, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR.

• SKU: CAY38802-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38802-1
• Package Unit: 1 mg
• Quantity Unit: STK