Application Note: IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 23
Positive Control: Breast carcinoma, skin
Form: Liquid
Buffer (with preservative): PBS, 0.1% BSA, 0.05% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
Uniprot ID: O95832
Antigen Species: Human
Immunogen: A synthetic peptide corresponding to C-terminal of human claudin 1
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: claudin 1
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