Application Note: WB: 0.1-0.25μg/ml. ICC/IF: 5μg/ml. IHC-P: 2-5μg/ml. FACS: 1-3μg/1x10⁶ cells. ELISA: 0.1-0.5μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 23
Form: Liquid
Buffer (with preservative): 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, no preservatives.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Uniprot ID: O15551
Antigen Species: Human
Immunogen: E.coli-derived human Claudin 3/CLDN3 recombinant protein (Position: A101-V220).
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: claudin 3
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