Target: ClCN3
Conjugate: APC
Product Type: Monoclonal
Clone Number: N258/5 (Formerly sold as S258-5)
Immunogen: Synthetic peptide amino acids 98-115 (cytoplasmic N-terminus) of rat Clcn3
Swiss-Prot: P51792
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~90kDa. Does not cross-react with Clcn4 or Clcn5 (based on KO validation results).
Cellular Localization: Membrane,Endosome,Endosome membrane,Cytoplasmic Vesicle,Secretory Vesicle Membrane
Scientific Background: Clcn3 mediates the exchange of chloride ions against protons, and functions as an antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could also help neuronal cells to establish short-term memory.
References: 1. www.phosphosite.org/proteinAction.do?id=5088&showAllSites=true
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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