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Encompassing Amino Acids: 60-191(end)
Application: Useful for SDS-PAGE.
Background: CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin like transcript -1) belongs to the NK cell receptor C-type lectin family of proteins. It functions as a ligand for the KLRB1 receptor (killer cell lectin-like receptor subfamily B member 1), also known as CD161, involved in sell recognition responses in NK cells. It is found in monocytes, NK cells and certain T cells. It plays a role in tumor and viral immunity and anti-inflammatory responses. It is also expressed in tumor cells, and the interaction between CLEC2D and CD161 in NK cells results in decreased cytotoxicity and IFNγ (interferon gamma) secretion. In the context of inflammation, CLEC2D transports DNA-histone complexes to endosomes and triggers TLR9 (toll like receptor 9) responses in macrophages and microglia. A deeper understanding on the roles of this protein can aid in the development of therapies for diseases that involved CLEC2D and its partners
Description: Recombinant human CLEC2D (C-type lectin domain family 2 member D), encompassing amino acids 60-191(end). This construct contains a N-terminal His-tag (6xHis) followed by an Avi-tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_013269
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-Avi-Tag
Uniprot: Q9UHP7
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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