Formulation: Lyophilized from sterile PBS, pH 7.0, 500 mM sodium chloride, and 10% glycerol
Purity: ≥90% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Colipase is a protein coenzyme required for the activity of pancreatic lipase.{64791,64789} It is a polypeptide secreted by the pancreas as inactive pro-colipase, which is activated via removal of a 5-amino acid pro-peptide by trypsin in the intestines. Colipase binds to the C-terminus of pancreatic lipase to facilitate hydrolysis of dietary triglycerides in the presence of bile salts.{64792,64788} Colipase deficiency induces steatorrhea, the excretion of excess fat in stool.{64790} Cayman's Colipase (human, recombinant) protein consists of 105 amino acids, has a calculated molecular weight of 11.5 kDa, and a predicted N-terminus of Ala18 after signal peptide cleavage.
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