Target: ATP7B
Conjugate: RPE
Product Type: Monoclonal
Clone Number: L62/29 (Formerly sold as S62-29)
Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
Swiss-Prot: B7ZLR4
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~160kDa in rat brain membrane preparations.
Cellular Localization: Cytoplasm,Mitochondrion,Golgi Apparatus,Trans-Golgi Network Membrane
Scientific Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.
References: 1. Tanzi R.E., et al. (1993) Nature Genetics. 5: 344-350.2. Ghr/nlm.gov/gene/ATP7B
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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