Formulation: A solid
Formal Name: 3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-2H-pyran-5-carboxylic acid, methyl ester
Purity: ≥98%
Formula Markup: C24H30O14
Formula Weight: 542,5
Shelf life (days): 1460
CAS Number: 131189-57-6
Notes: Cornuside is a bisiridoid glycoside that has been found in C. officinalis and has diverse biological activities.{62905,62906,62907,62908} It induces osteogenic differentiation of isolated human bone mesenchymal stem cells (BMSCs) when used at concentrations of 10, 30, and 60 µM.{62905} In vivo, cornuside (150 mg/kg) reduces demyelination, focal inflammation, and T helper 17 (Th17) cell spinal cord infiltration, as well as improves neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE).{62906} Cornuside (0.4 and 0.8 mg/kg) decreases mortality, vascular instability, and pulmonary leukocyte infiltration in a mouse model of cecal ligation and puncture-induced sepsis.{62907} It also reduces polydipsia and polyphagia, lowers fasting blood glucose levels, prevents testicular cell apoptosis, and decreases the abundance of Weissella, Clostridium, Anaerotruncus, and Bilophila in the gut microbiome in KK/Ay diabetic mice.{62908}
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