Products from BPS Bioscience require a minimum order value above 400€
Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput screen (HTS) applications.
Background: Colony Stimulating Factor 1 Receptor (CSF1R, also known as CSFR, CD115, and M-CSF-R) is a tyrosine kinase transmembrane receptor activated either by CSF1 (MCSF) or interleukin-34 (IL-34), causing homodimerization and activation of the kinase activity. CSF1R is expressed on the surface of monocytes and macrophages, controlling their growth, survival, or differentiation. A number of tumor cells overexpress the cytokine CSF1, driving the development and survival of Tumor-Associated Macrophages, which in turn suppress the local immune response to the cancer
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The CSF1R Kinase Assay Kit is designed to measure CSF1R kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant CSF1R kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: P07333
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
English
Deutsch
