Formulation: A solid
Formal Name: (SP-4-2)-[[2, 2′-(1,2-dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper
Purity: ≥98%
Formula Markup: C18H18CuN6S2
Formula Weight: 446,1
Shelf life (days): 730
CAS Number: 68341-12-8
Notes: Cu-ATSP is a copper-containing bis(thiosemicarbazone) complex with ferroptosis inhibitory activity.{67109} It traps peroxyl radicals in a cell-free assay when used at a concentration of 6 µM. Cu-ATSP inhibits ferroptosis induced by (1S,3R)-RSL3 (Item No. 19288) in Pfa1 mouse embryonic fibroblasts (MEFs) and HT22 mouse hippocampal cells (EC50s = 8.5 and 16 nM, respectively). It increases intracellular copper levels but, unlike the bis(thiosemicarbazone) complexes Cu-CQ2 and CuNC2, does not reduce amyloid-β (1-40) (Aβ40) levels in CHO cells overexpressing amyloid precursor protein (APP).{67110}
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