Formulation: A solid
Formal Name: (SP-4-2)-[[2,2′-(1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato-κN2,κS]](2-)]-copper
Purity: ≥95%
Formula Markup: C6H10CuN6S2
Formula Weight: 293,9
Shelf life (days): 730
CAS Number: 68341-14-0
Notes: Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM (Item No. 17122) that has diverse biological activities.{58920,58921,58922,58923} It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC50s = 0.3-0.6 µM for all).{58920} Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC50s = 0.009 and 0.27 µM, respectively).{58921} It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.{58922} Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer's disease.{58923}
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