Formulation: A solid
Formal Name: (2β,9β,10α,16α,23E)-2,16,20,25-tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
Purity: ≥98%
Formula Markup: C30H44O7
Formula Weight: 516,7
Shelf life (days): 1460
CAS Number: 3877-86-9
Notes: Cucurbitacin D is a triterpenoid that has been found in Cucurbita texana and has diverse biological activities.{69087,69088,69089} It decreases levels of the heat shock protein 90 (Hsp90) client proteins HER2, Raf, and cyclin-dependent kinase 6 (Cdk6) in MCF-7 breast cancer cell lysates in a concentration-dependent manner and inhibits the proliferation of MCF-7 cells (IC50 = 0.598 µM).{69087} Cucurbitacin D (0.1 µM) inhibits cigarette smoke condensate-induced HIV-1 replication in chronically HIV-1-infected U1 macrophages.{69088} In vivo, cucurbitacin D (0.025 mg/kg) decreases cold and mechanical allodynia in a mouse model of neuropathic pain induced by paclitaxel (Item No. 10461).{69089}
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