Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)(CCND1/3548), 1mg/mL

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Description: Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: CCND1/3548

Entrez Gene ID: 595

Immunogen: Recombinant fragment of human CCND1 (around aa 115-270) protein (exact sequence is proprietary)

• SKU: BTMBNUM3548-50
• Manufacturer: Biotium
• Manufacturer SKU: BNUM3548-50
• Package Unit: 50 uL
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b kappa
• Host: Mouse
• Conjugate: Unconjugated