Product Type: Inhibitor
CAS No.: 59865-13-3
MolecularFormula: C62H111N11O12
Molecular Weight: 1202,63
Source: Synthetic
Purity: >99%
Solubility: Soluble to 100 mM in DMSO, 50 mM in ethanol
Appearance: White Solid
PubChem CID: 5284373
Scientific Background: Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
References: 1. Heitman J., et al. (1992) New Biol. 4:448.2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.