Formulation: A neat oil
Formal Name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, cyano[3-(phenoxy-2,3,4,5,6-d5)phenyl]methyl ester
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H14Cl2D5NO3
Formula Weight: 421,3
Shelf life (days): 1460
CAS Number: 2140327-50-8
Notes: Cypermethrin-d5 is intended for use as an internal standard for the quantification of cypermethrin (Item No. 24117) by GC- or LC-MS. Cypermethrin is a type II pyrethroid insecticide.{40965,40966,40967,40968} It prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system, and point mutations in sodium channels induce cypermethrin-resistance in house flies, cockroaches, and mosquitos.{40967} Cypermethrin (1-1.5 mg) reduces survival of ticks (H. anatolicum) in vitro in a concentration-dependent manner.{40966} Topical administration of cypermethrin reduces the number of ticks on infested cattle. Cypermethrin (5 and 10 ppm) reduces survival of lice (D. ovis) in sheep fleece and prevents re-infestation in contact-challenged sheep for 7 and 19 weeks, respectively.{40965} It induces developmental neurotoxicities in zebrafish, increasing mortality and edema and inducing body-axis curvature when used at concentrations ranging from 50 to 200 μg/L.{40969} Cypermethrin (15 mg/kg twice weekly for 24 weeks) also induces Parkinson's disease-like neurodegeneration in rats, decreasing locomotor activity, dopamine production, and the number of tyrosine hydroxylase positive (TH+) neurons in the substantia nigra.{40968} Formulations containing cypermethrin have been used in the control of insects in agriculture and on commercial and residential premises.
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