Cys-McMMAF, CAS 1160590-05-5

Product Description: Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1].

Applications: Cancer-programmed cell death

Formula: C52H83N7O13S

References: [1]Leal M, et al. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32.

CAS Number: 1160590-05-5

Molecular Weight: 1046.32

Compound Purity: 99.91

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: Microtubule/Tubulin

• SKU: MEXHY-150233-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-150233-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK