Specificity: This antibody recognizes a 52.5kDa protein known as Cytokeratin 8. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Immunogen: Cytoskeletal extract of Hep3B hepatocellular carcinoma cell line of human origin