Formulation: A solid
Formal Name: D-glucuronic acid, γ-lactone
Purity: ≥98%
Formula Markup: C6H8O6
Formula Weight: 176,1
Shelf life (days): 1460
CAS Number: 32449-92-6
Notes: D-Glucurone is an intermediate in the glucuronic acid pathway.{51677,51678} It is formed from D-glucuronic acid (Item No. 31531) spontaneously or by uronolactonase and is converted to L-ascorbic acid (Item No. 14656) via a L-gulonolactone intermediate. D-Glucurone (1 µg/ml) prevents increases in alanine transaminase (ALT) and aspartate aminotransferase (AST) activities, as well as malondialdehyde (MDA) levels, and protects against decreases in cell viability, superoxide dismutase (SOD) activity, and glutathione (GSH) levels, induced by the mycotoxin ochratoxin A (Item No. 11439) in primary chicken hepatocytes.{51679} In vivo, D-glucurone (1 mg/ml in the tank water) prevents decreases in neuronal excitability and reverses deficits in a visual avoidance assay in a Xenopus model of neurotoxicity induced by the solvent p-xylene.{51676}
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