Product Description: Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases[1][2].
Applications: COVID-19-immunoregulation
Formula: C4H7NO2S
References: [1]Sánchez-Fernández A, et, al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Immunol. 2019 Nov 1;10:2578./[2]Toldo S, et, al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222.
CAS Number: 54863-37-5
Molecular Weight: 133.17
Compound Purity: 98.0
Research Area: Inflammation/Immunology; Cancer
Solubility: DMSO : ≥ 100 mg/mL/H2O : 36.67 mg/mL (ultrasonic)
Target: NOD-like Receptor (NLR)
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