Product Type: Inhibitor
CAS No.: 208255-80-5
MolecularFormula: C23H26F2N2O4
Molecular Weight: 432,46
Source: Synthetic
Purity: >99%
Solubility: Soluble to 100 mM in DMSO
Appearance: White to off-white powder
PubChem CID: 5311272
Scientific Background: Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. Does not affect APPα and APPβ levels. Blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
References: 1. Dovey H.F., et al. (2001) J. Neurochem. 76(1): 173-81. 2. De Smedt M., et al. (2005) Blood. 106(10): 3498-506.3. Kanungo J., et al. (2008) J. Neurochem. 106(5): 2236-48.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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