DBCO-(PEG2-VC-PAB-MMAE)2, CAS 2259318-55-1

Product Description: DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate[1]. DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C149H224N22O32

References: [1]Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.

CAS Number: 2259318-55-1

Molecular Weight: 2835.50

Compound Purity: 98.73

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Drug-Linker Conjugates for ADC

• SKU: MEXHY-126690-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-126690-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK