Product Description: DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Applications: Cancer-programmed cell death
Formula: C36H43N3O11
References: [1]Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497./[2]Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.
CAS Number: 2144395-59-3
Molecular Weight: 693.74
Compound Purity: 95.06
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: ADC Linker;PROTAC Linkers
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