Formulation: A crystalline solid
Formal Name: (3β)-cholest-5-en-3-ol 3-[N-[2-(dimethylamino)ethyl]carbamate], monohydrochloride
Purity: ≥95%
Formula Markup: C32H56N2O2 • HCl
Formula Weight: 537,3
Shelf life (days): 730
CAS Number: 166023-21-8
Notes: DC-Chol is a cationic cholesterol derivative.{47233} DC-Chol, as a component of lipoplexes with 1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE; Item No. 15091), has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/1,2-DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.{47234,47235,47236,47237}
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