DCLK1-IN-1, CAS 2222635-15-4

Product Description: DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1+ pancreatic ductal adenocarcinoma (PDAC)[1].

Applications: Cancer-Kinase/protease

Formula: C26H28F3N7O2

References: [1]Ferguson FM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Apr 6.

CAS Number: 2222635-15-4

Molecular Weight: 527.54

Compound Purity: 99.62

Research Area: Cancer

Solubility: DMSO : 35.71 mg/mL (ultrasonic)

Target: Fluorescent Dye

• SKU: MEXHY-135985-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-135985-100
• Package Unit: 100 mg
• Quantity Unit: STK