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Encompassing Amino Acids: 467-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain (1) and is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung (2).
Description: Recombinant human DDR2 (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_006182.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_006182
Host Cell Line: Sf9 cells
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q16832
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Karn, T. et al. Oncogene 8: 3433-3440, 1993.
2. Ferri, N. et al. Am J Pathol. 2004 May,164(5):1575-85.
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