Description: Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the main active metabolite of amiodarone.
CAS Number: 96027-74-6
Formula: C23H26ClI2NO3
Molecular Weight: 653,72
References: Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50.