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Clone Name: MSVA-543M
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
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Application Note: IHC-P: 1:75-1:150. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 108
Positive Control: Tonsil: A moderate to strong desmoglein 3 immunostaining should be seen in a fraction of squamous epithelial cells.
Negative Control: Tonsil: Desmoglein 3 immunostaining should be absent in all non-squamous epithelial cell types.
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for BSA and azide free format), 0.05% sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016]
Uniprot ID: P32926
Antigen Species: Human
Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: desmoglein 3
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