Product Description: Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases[1][2][3][4].
Applications: COVID-19-immunoregulation
Formula: C11H18Cl2N4O4
Citations: Environ Toxicol Pharmacol. 2023 Sep 7;104261./Nat Med. 2016 May;22(5):547-56. /Adv Sci (Weinh). 2023 Mar 26;e2206007./Biochem Pharmacol. 2024 Apr 30:224:116247./Biomed Pharmacother. 2022 Jun 17;153:113280./Cardiovasc Toxicol. 2024 Jun 19./Eur J Med Chem. 2024 Nov 26:283:117108./Free Radic Biol Med. 2020 Nov 20;160:303-318./Free Radic Biol Med. 2024 Dec 9:227:296-311./Mol Med Rep. 2024 May;29(5):84./Nano Res. 2023 Apr 18./Phytomedicine. 2023 Jun 10, 154922.
References: [1]Jenna Kropp, et al. Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. PLoS One. 2015 Nov 6;10(11):e0142588. /[2]A R Imondiv, et al. Dose-response relationship of dexrazoxane for prevention of doxorubicin-induced cardiotoxicity in mice, rats, and dogs. Cancer Res. 1996 Sep 15;56(18):4200-4./[3]Meng Mei, et al. Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease. Neuropharmacology. 2019 Dec 1:160:107758./[4]Shiwei Deng, et al. The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells. Br J Pharmacol. 2015 May;172(9):2246-57.
CAS Number: 149003-01-0
Molecular Weight: 341.19
Compound Purity: 99.83
Research Area: Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 20 mg/mL (ultrasonic)
Target: Others
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