Product Description: DGN549-C consists a cleavable ADC linker valine-alanine (va) and PBD dimer. DGN549 is a novel DNA-alkylating cytotoxic payload and can be used in the synthesis of antibody-agent conjugates (ADCs)[1].
Applications: Cancer-programmed cell death
Formula: C60H61N9O12
References: [1]Chen Bai, et al. Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates With an Improved Therapeutic Index as Compared With Lysine Conjugation. Bioconjug Chem