Product Description: Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM)[1].
Applications: COVID-19-immunoregulation
Formula: C22H17Cl2N3O2S
References: [1]Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24.
CAS Number: 724453-98-9
Molecular Weight: 458.36
Compound Purity: 99.67
Research Area: Inflammation/Immunology
Solubility: DMSO : 83.33 mg/mL (ultrasonic)
Target: Epoxide Hydrolase;FLAP
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