Product Type: Inducer
CAS No.: 13031-64-6
MolecularFormula: C20H41NO3
Molecular Weight: 343,54
Source: Synthetic
Purity: ≥98%
Solubility: Soluble in ethanol (5 mg/ml) or DMSO (5 mg/ml: dissolve in hot DMSO, then cool to RT).
Appearance: White solid.
PubChem CID: 6610273
Scientific Background: Both in yeast and mammalian systems, dihydroceramide is the reaction intermediate found immediately prior to the final reaction product in the de novo synthesis of ceramide lipids. Recent studies have revealed that an accumulation of dihydroceramide will induce autophagy. Accumulation of dihydroceramide occurs due to inhibition of dihydroceramide desaturase, the enzyme responsible for the conversion of dihydroceramide into ceramide.
References: 1. Gagliostro, V. et al. (2012). Int J Biochem Cell Biol, 44(12): 2135-43.2. Jiang, Q. et al. (2012). Int J Cancer, 130(3): 685-93.3. Signorelli, P. et al. (2009). Cancer Lett, 282(2): 238-43.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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