Product Type: Inhibitor
CAS No.: 89464-63-1
MolecularFormula: C6H9NO5
Molecular Weight: 175,1
Source: Synthetic
Purity: >99%
Solubility: Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml)
Appearance: Off-white solid
PubChem CID: 560326
Scientific Background: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.
References: 1. Grozinger C.M., et al. (2001) J. Biol. Chem. 276(42): 38837-43. 2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95. 3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71.4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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