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Encompassing Amino Acids: 1-520
Background: DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).
Description: Recombinant Human DLK, also known as MAP3K12, MUK, and ZPK. Genbank Accession #NM_006301, a.a. 1-520, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 10mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_006301
Purity: ≥75%
Storage Stability: At least 6 months at -80°C. Avoid freeze/thaw cycles.
Tags: GST-Tag
Uniprot: Q12852
Biosafety Level: Not applicable (BSL-1)
References: 1.Hirai, S., et al., Oncogene 2011;12:641-650.2.Ferron, S., et al., Nature. 2011;475:381-385.
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