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Encompassing Amino Acids: 24-303
Background: Delta like non-canonical Notch ligand 1 (DLK1), also known as Protein delta homolog 1, is a cleavable single-pass transmembrane protein with a restrict pattern of expression (neuroendocrine tissues and progenitor cells). It plays a role in neuroendocrine differentiation and regulates adipose tissue homeostasis. Low levels of the protein are associated with acromegaly. Overexpression of DLK1 is observed in endocrine-related cancers, such as ovarian and adrenocortical cancer, and associated with a poor prognosis. It is considered a promising therapeutic target for such malignancies.
Description: Delta like non-canonical Notch ligand 1 (DLK1), encompassing amino acids 24-303. This construct contains a C-terminal Avi-tag™ followed by a His-tag (6xHis). The recombinant protein was affinity . HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_003836.6
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™, His-Tag
Uniprot: P80370
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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