Product Description: DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
Applications: Cancer-programmed cell death
Formula: C39H56ClN3O10S2
References: [1]Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73./[2]Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
CAS Number: 796073-68-2
Molecular Weight: 826.46
Compound Purity: 98.0
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: ADC Cytotoxin;Microtubule/Tubulin