Notes: DMG-PEG(2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).{60496} Administration of fumarylacetoacetate hydrolase (FAH) mRNA in DMG-PEG(2000)-containing LNPs increases survival in a mouse model of hereditary tyrosinemia type 1 (HT-1). Formulations containing DMG-PEG(2000) have been used in the development of LNPs for the delivery of mRNA-based vaccines.