Formulation: A crystalline solid
Formal Name: (3β)-cholest-5-en-3-ol 3-[N-[3-[(2-hydroxyethyl)dimethylammonio]propyl]carbamate]
Purity: ≥95%
Formula Markup: C35H63N2O3
Formula Weight: 559,9
Shelf life (days): 730
CAS Number: 794494-38-5
Notes: DMHAPC-Chol is a cationic cholesterol.{47185} Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 µM. DMHAPC-Chol, as part of a lipoplex with DOPE (Item No. 15091), has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.{47186,47187}
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